Pharmacology 3620 Lecture Notes - Lecture 17: Felodipine, Neuroplasticity, Mitochondrion
25 Apr 2018
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Dysphoric and/or loss of interest and pleasure in all activity. Thought to be a malfunction in the pleasure-reward system in the brain. Things that are normally pleasurable are no-longer pleasurable. Associated with changes in appetite, sleep disturbance, decreased psychomotor activity, decrease energy and feelings of worthlessness, difficulty concentrating and making decision and thoughts of death. 15% of those people die from committing suicide. Elevated, expansive, and irritable moods which may include inflated self esteem. Excessive tendency to engage in pleasurable activities that may. Increased goal oriented behaviour be dangerous and potential painful. On the depressed side, depression will be similar to unipolar disorder. Cycle between manic/depressive stage interspersed with periods of normal behaviour is highly variable. Lasts from a few hours to a few months. Major classes of drugs used to treat depression. Recall: neurotransmitters in the nerve terminal signals must be terminated. Serotonin and norepinephrine are reuptake from the synaptic cleft. This process can be blocked by drugs.
