Pharmacology 2060A/B Lecture Notes - Lecture 11: Kidney Disease, Cyp2D6, Anticoagulant
30 Jul 2018
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Drug/food interactions: monoamine oxidase inhibitors (antidepressants) (mao, cant eat tyramine foods bc mao inhibit its breakdown. Aged cheese, yeasy, red wine, cured meat: cause increased norepinephran hyperensive crisis module 14 case study. Halls strepsils antiseptic+ anaesthetic: meds and concentrations in the blood sertraline 44. 8 ng/ml. Alprazolam 604ng/ml clozapine 13. 3 ng/ml triazolam not detected. Multivitamins: sespsis secondary to bacterial infection, neutrocells (5 cells/mm) low, what are they used for, sertraline: Benzodiazepine for anxiety therapeutic range 20-30 ng/ml: clozapine: Tr : what are the therapeutic ranges, significance of neutrophil count (did it play a role, clozapine can casue severe neutropenia. Module 10: adverse reactions idiosyncratic reactions: cyp2c9 teratogenic. Medication errors: most common cause of adverse reaction. In extensively metabolized drugs, half life is increased. Ionized drug cannot penetrate cell memebrane: most drugs are weak bases . move more easily in basic environment, an acidic drug will move to a basic environment but cannot move out of it, vice versa, lipophilic molecules.
