Pharmacology 2060A/B Lecture Notes - Lecture 5: Distal Convoluted Tubule, Proximal Tubule, Kidney Disease
24 Oct 2018
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Document Summary
Is the removal of parent drug and drug metabolites from the body: most common sites of drug excretion are the kidney and the bile. If the drug is uncharged or lipid soluble, it"s able to leave the tubule and be reabsorbed back into the blood. If renal function is decreased, renal drug excretion is decreased. Portal vein: carries blood from the intestine to the liver blue structure: 2. Parent drug: in the portal vein red circle: 4. Bile canaliculus: thin tube that collects bile and drugs excreted by the liver green: 3. Hepatic duct: takes bile and drugs from liver to gall bladder, where they can then be secreted back to the intestine: 6. Metabolized drug: a phase ii metabolized drug being carried in the hepatic duct from the liver to the gall bladder: this drug is in the process of undergoing biliary excretion. It will be released by gall bladder back into the intestine.
