Pharmacology 3620 Lecture Notes - Lecture 7: Cholesteryl Ester, Hyperlipidemia, Very Low-Density Lipoprotein
24 Nov 2017
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Document Summary
Comes from intestine, after a meal, need to transport bits of lipid taken from the meal through the body effectively. Whenever the lipid has plenty of lipid available it can transport lipid to other parts of the body by assembling and secreting vldls. As vldl reaches wider circulation, lipid core gets hydrolyzed > smaller particle, ldl, is rich in cholesterol esters. Small molecule carrying cholesterol away from peripheral tissues back to the liver. Lipid plaques build up in the vessel wall, depending on the arteries affected, you have different disease outcomes. As they develop, your vessel will respond by providing a smooth muscle layer to stabilize that plaque. Problem occurs whe you get occlusion (blockage) of the artery or plaque rupture (plaque cap weakens > thrombosis) Endothelial cell damage, can be enough space that ldl particles go into the vessel wall. Once ldl enters that space it can be rapidly oxidized (good chemotatic agent)
