Pharmacology 3620 Lecture Notes - Lecture 6: Pharmacodynamics, Pharmacology, Covalent Bond
6 Jan 2021
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Document Summary
Introduction: pharmacodynamics is the quantitative description of the effect of a drug on the body, most (but not all) drugs exert their effects by binding to specialized macromolecules (ex receptors, enzymes) Receptors basics: drugs can be thought of as signals that we send to the cell, receptors can be through of as detectors that detect that signal. Types of interactions between drugs and receptors: rare that one type of bond causes drug receptor binding; rather, it is usually a combination of bonds, generally many weak bonds make up a drug-receptor interaction, vdw and h bonds. It is often useful to know what fraction of receptor is occupied by a drug. Ibuprofen is more potent because 200mg will produce the same effect as taking 325mg of acetaminophen: efficacy the ability of a drug to elicit a response when it binds to its.
