Pharmacology 3620 Lecture Notes - Lecture 1: Median Toxic Dose, Warfarin, Partial Agonist
9 Dec 2015
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Document Summary
Pharmacodynamics: quantitative description of the e ect of a drug on the body. Most drugs exert e ect by binding to specialized macromolecules (receptors, enzymes). Receptor: can be thought of as a detector, detecting the signal (drug). Usually a combination of bonds/forces that make up a drug-receptor interaction, rarely just one. The law of mass action: the rate of a chemical reaction depends on the concentration of the reactants. Neither the drug or receptor is altered by the process. The equilibrium dissociation constant (kd): the a nity of a drug-receptor pair. Fractional receptor occupancy: what fraction of receptors are occupied by a drug. Large is high a nity, small is low a nity. Dose response curve: magnitude of response most often directly related to amount of drug that occupies its receptor (exception when there are spare receptors). none relationships ie. death). Graded: shows continuous relationship between dose and response.
