Pharmacology 3620 Lecture Notes - Lecture 2: Autoimmune Thyroiditis, Basal Metabolic Rate, Iodised Salt
4 Apr 2016
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Document Summary
Hypothalamic pituitary-thyroid axis is a part of the neuroendocrine system. Trh (thyrotropin releasing hormone) released by the hypothalamus. Simulates cells of anterior pituitary to secrete tsh (thyroid simulaing hormone) Tsh binds to receptor on thyroid follicle cells, increases the synthesis of thyroid hormone. Thyroid is not essenial for life but is important. Thyroid receptors present in the nuclei of most cells of the body. Regulate basal metabolic rate in adults by: simulaion of na/k atpase, simulaion of carb absorpion from intesine, release of fas from adipocytes, upregulation of beta-adrenergic receptors in many issues, including heart and nervous system. Maintain constant levels of thyroid hormone depends on negaive feedback efects, inhibiing synthesis and secreion of tsh and trh (homeostasis) Follicle and colloid: site of thyroid hormone synthesis: uptake of iodine in the follicle, synthesis of thyroglobulin in the follicle. 3: condensaion in the colloid making t3 (triiodothyroxine) and t4 (thyroxine, proteolyic release of hormone (t3 and t4)
