Physiology 2130 Lecture Notes - Lecture 6: Paracrine Signalling, Laminal Consonant, Natriuresis

• School: Western University
• Department: Physiology
• Course: Physiology 2130
• Professor: Anita Woods

Document Summary

Juxtamedullary: long loop of henle, closer to the medulla, renal corpuscle, part of the nephron that filters blood and produces a fluid called the ultra-filtrate. Inhibits filtration: h(cid:455)d(cid:396)ostati(cid:272) p(cid:396)essu(cid:396)e of bo(cid:449)(cid:373)a(cid:374)"s capsule (cid:894)pbc, p(cid:396)essu(cid:396)e (cid:272)aused (cid:271)(cid:455) filt(cid:396)ate (cid:396)e(cid:373)ai(cid:374)i(cid:374)g i(cid:374) bo(cid:449)(cid:373)a(cid:374)"s spa(cid:272)e, 15 mmhg. Inhibits filtration: colloid os(cid:373)oti(cid:272) p(cid:396)essu(cid:396)e of bo(cid:449)(cid:373)a(cid:374)"s capsule (cid:894) bc, p(cid:396)essu(cid:396)e (cid:272)aused (cid:271)(cid:455) the p(cid:396)ese(cid:374)(cid:272)e of p(cid:396)otei(cid:374)s i(cid:374) bo(cid:449)(cid:373)a(cid:374)"s (cid:272)apsule, promotes filtration, 0 mmhg, usuall(cid:455) do(cid:374)"t ha(cid:448)e p(cid:396)otei(cid:374)s i(cid:374) bo(cid:449)(cid:373)a(cid:374)"s (cid:272)apsule, since bc = 0 mmhg. Net filtration pressure = (pgc + bc) (pbc + gc) Net filtration pressure = (pgc) (pbc + gc) Net filtration pressure = (55) (15+30) = 10 mmhg. If nfp > 10 mmhg, filtering too much. If nfp < 10 mmhg, filtering too little: glomerular filtration rate (gfr, the a(cid:373)ou(cid:374)t of fluid/solutes that a(cid:396)e filte(cid:396)ed pe(cid:396) u(cid:374)it ti(cid:373)e i(cid:374)to bo(cid:449)(cid:373)a(cid:374)"s spa(cid:272)e from the glomerular capillaries, factors that affect gfr, net filtration pressure.