Physiology 2130 Lecture Notes - Lecture 40: Cholecalciferol, Urobilin, Calcitriol
1 May 2018
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Lecture 040: Renal Physiology
Urine can tell you a lot about of the health of the individual
● Production of urine very important
Overview of Kidney Function
● Regulation of the ionic composition of blood
○ The kidney process and filter the product of the blood
○ Decided how much of the ion is released back into the blood or excreted in the
urine
■ Urine is the byproduct of the ion balancing
● Regulation of blood pH
○ Very important for proteins to stay in their conformation
● Regulation of blood volume
○ Insures the blood volume is appropriate by excrete a appropriate volume of urine
● Regulation of blood pressure
○ Works with the heart to maintain the BP
○ Responds to baroreceptors and volume receptors
○ Adjust the filtered product it produces based on the information it receives
● Maintenance of blood osmolarity
○ Osmolarity refers to ALL the solutes dissolved into the blood
● Production of hormones
○ Erythropoietin (EPO)
■ Helps stimulate RBCs production
○ Activated Vitamin D (Calcitriol)
■ Steroid hormone, cause gene expression changes
■ Kidney converts vitamin D into its active forms (calcitriol)
■ Can obtain vitamin D by eating greens (vitamin D 2) or by sun exposure
(vitamin D 3)
● Regulation of blood glucose levels
○ Gluconeogenesis
■ Making glucose from protein and fats
○ Makes sure there is sufficient levels of glucose for the brain
● Excretion of waste products and foreign substances
○ Metabolic waste produces
■ Ura (breakdown of protein)
■ Uric acid (breakdown of nucleotide)
■ Creatinine (breakdown of creatine- high energy carrier in muscle )
■ Urobilin (breakdown of hemoglobin)
Kidney
● Normally we are born with tow
○ But one kidney is sufficient to function on
● Cortex (outer layer)
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Document Summary
Urine can tell you a lot about of the health of the individual. Regulation of the ionic composition of blood. The kidney process and filter the product of the blood. Decided how much of the ion is released back into the blood or excreted in the urine. Urine is the byproduct of the ion balancing. Very important for proteins to stay in their conformation. Insures the blood volume is appropriate by excrete a appropriate volume of urine. Works with the heart to maintain the bp. Adjust the filtered product it produces based on the information it receives. Osmolarity refers to all the solutes dissolved into the blood. Kidney converts vitamin d into its active forms (calcitriol) Can obtain vitamin d by eating greens (vitamin d 2) or by sun exposure (vitamin d 3) Makes sure there is sufficient levels of glucose for the brain. Excretion of waste products and foreign substances.
