Physiology 3140A Lecture Notes - Lecture 3: Protein Precursor, Angiogenesis, Osteoarthritis

• School: Western University
• Department: Physiology
• Course: Physiology 3140A
• Professor: John Di Guglielmo

Document Summary

Secreted by cells into the spaces that surround them: dermis: fibroblasts produce the extracellular matrix. In the dermis, there are a few fibroblasts and a lot of ecm: mostly connective tissue, epithelium: not a lot of ecm, basal cells in the epidermis produce the basal membrane. Extracellular matrix can have different functions depending on the cells that produce them. Many functions: structural (bone and teeth, tensile strength (tendons, transparent matrix for sight (cornea, control cell behavior (basal lamina at interface between epithelium and connective tissue) Dermis is a structure in the skin that contains connective tissue (ecm + fibroblasts: connective tissue around the bone and in other places will be different. Epithelial cells can be one layer thick (with one side facing the lumen and one side facing the ecm) or they can be multiple layers thick like the skin. Basal lamina and the matrix are different in structure despite them both being collagen- based.