Psychology 3316F/G Lecture Notes - Lecture 12: Bipolar Disorder, Corticosterone, Rodent

• School: Western University
• Department: Psychology
• Course: Psychology 3316F/G
• Professor: ferwen

Document Summary

Neurobehavioural endophenotypes: intermediate markers between top-level symptoms & bottom- level genetic contributions. Important to focus simultaneously on at least two separable elements of animal models: e. g. , behaviour & brain processes. Heritability estimates for most psychiatric disorders approximate 50%*** & certai(cid:374) disorders highly heritable. Most clearly obtained by comparing co- prevalence btw mz vs dz twins on assu(cid:373)ptio(cid:374) of (cid:858)shared e(cid:374)viro(cid:374)(cid:373)e(cid:374)t(cid:859) Variants of small effect: common in gen. pop. Variants of large effect: rare in gen. pop. & may have lg. effect in predicting dx. Argument that some mis may be uniquely human. Most current psychiatric disorders do not map neatly onto genetic/physio abnormalities. Disease model: face validity (minimal goal), mimic behaviour (rodent analogs, construct validity (maximal goal), risk factors, course, treatment response. Limitations: failure to model complex socioemotional states (e. g. , guilt, shame) The analysis of anxious and fearful behavior in terms of basic associative conditioning mechanisms both. Pavlovian and instrumental components, augmented by vicarious (observational) learning & biological preparedness.