Psychology 3316F/G Lecture Notes - Lecture 15: Model Organism, Posttraumatic Stress Disorder, Face Validity

• School: Western University
• Department: Psychology
• Course: Psychology 3316F/G
• Professor: ferwen

Document Summary

Neuro-behavioural endophenotypes: intermediate markers between top-level symptoms & bottom- level genetic contributions. Important to focus simultaneously on at least two separable elements of animal models: e. g. , behaviour & brain processes: and see the correlation between them. Intermediate is info processing can measure it psychologically through reacting time, but in an animals looking at physiological level takes gene and environment info and applies it get an outcome in behavior and experience. Heritability estimates for most psychiatric disorders approximate 50%*** & certain disorders highly heritable ~80% in bipolar disorder: 50/50 genes/environment, could be higher in other disorders e. g. bipolar, but ptsd is pretty close to 50/50. Most clearly obtained by comparing co- prevalence btw mz vs dz twins on assumption of shared environment". Variants of small effect: common in gen. pop. & have sm. effect in predicting dx: all the genes that are going to be labeled are almost always of small effects its not going to be one gene, its combination.