CH250 Lecture 2: Lecture 2
Document Summary
Figure 1. 1 biochemical reactions are often studied or used in in vitro systems. Eduard buchner (1860 1917) was the first to demonstrate that cell-free yeast extracts could accomplish in vitro fermentation of sugar into alcohol and carbon dioxide, a discovery that led to the birth of modern biochemistry. Buchner was awarded the 1907 nobel prize in chemistry for his ground- breaking research on in vitro fermentation. Figure 1. 2 the yeast enzymes pyruvate decarboxylase and alcohol dehydrogenase are responsible for converting pyruvate, a product of glucose metabolism, into alcohol and carbon dioxide. Pyruvate/pyruvic acid can remove a h (so an acid) Alcohol dehydrogenase adds a h to nadh, then 2 hs are added to acetaldehyde becoming ethanol. In humans pyruvate converted to lactic acid (in muscles) Too much ethanol: exceed capacity of enzyme"s ability to metabolize lead to hangover. Figure 1. 3 applied biochemistry uses a basic understanding of biochemical principles to guide advances in agriculture, medicine, and industry.
