BIOL 4510 Lecture Notes - Lecture 12: Phosphoenolpyruvic Acid, Titin, Tnni3
Document Summary
Force generation involves the interaction of thick and thin filaments. In skeletal and cardiac muscle this is controlled by ca2+ binding to the troponin-tropomyosin complex located on the thin filament. The regulation of force generation by ca2+ is highly cooperative which allows force to be turned on over a very narrow range of ca2+ levels. For smooth muscle the force is regulated by phosphorylation of the regulatory mlc-2 by myosin-light-chain kinase, which is activated by a number of signaling pathways, many of which are activated by ca2+ so there is still ca2+ regulation. Process of (skeletal muscle excitation http://www. youtube. com/watch?v=cepeyfvqmk4 http://www. youtube. com/watch?nr=1&v=mwpmuqrzyls&feature=endscreen http://www. youtube. com/watch?nr=1&v=edhzkydxrkc&feature=endscreen. Cross-bridge cycle: http://www. youtube. com/watch?v=gj309lfhq3m view these two videos together. http://www. youtube. com/watch?feature=fvwp&v=avv94fapnp8&nr=1 http://www. youtube. com/watch?nr=1&v=zqocslrm7_a&feature=fvwp. Site of (most of) ca2+ regulation of contraction in heart and skeletal muscle. 4 human tropomyosin genes: tpm1 ( ), tpm2 ( ), tpm3 (slow ) and tpm4. In striated muscle (skeletal and cardiac) muscle, the principal tm"s are and .
