PHIL 2130 Lecture Notes - Lecture 20: Metaraminol, Ritodrine, Baroreflex
6 May 2020
School
Department
Course
Professor
Document Summary
Effects are hard to predict (most in cns) Good because you do not want vasodilation. During heart failure want to bp to keep the heart going. Mech involves cns long duration of action. Decreases peripheral resistance due to 2 effects. Increased heart rate and contractility due to direct 1 effect and due to baroreflex-induced tachycardia. Designed to be a selective dopamine receptor agonist. Turns out to be very selective for 1 receptor. Used to treat congestive heart failure (chf) Treat with corticosteroids to reduce risk of neonatal respiratory diseases. Inhalation has low systemic absorption which will have fewer side effects like: Leukotriene and histamine release from pulmulory mast cells (aka local. Effect of 1 and low affinity for 2. Not used therapeutically due to abuse potential. Similar to cocaine but longer lasting effects. Some direct receptor activity and some modified indirect.
