PHIL 2130 Lecture Notes - Lecture 13: Partition Coefficient, Dosage Form, Lipid Bilayer
6 May 2020
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Document Summary
Ion movement in porous soil/concrete: geology, civil engineering. Doped ions in semiconductors: electrical engineering. The size of dose determines difference between steady state max. and steady state min. The mass movement of things through convection depends on temp as well. But, drug movement on body requires focus on diffusion (on the nanonemeter scale- very small random movements). And, all of these depend on first-order processes: barriers, gi barrier -> blood, drug moves in random direcitons and when it hits lipid membrane, it might enter it. Once it enters lipid membrane, it starts moving in different directions. And, then there"s a big probability that drug will enter other part of membrane and enter aqeous side. The key here is that all these movements are random: but, if the drug does cross the barrier, because there is a high statistical probability that drug will move from high concentration to low concentration. Diffusion- is seen in inhalation and topical application as well.
