SOCI 3630 Lecture Notes - Lecture 42: Gliclazide, Glimepiride, Glibenclamide
4 Jun 2020
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Increases insulin sensitivity in the liver and peripheral tissues. Shorter acting secretagog ues than sulfonylure as. Gi disturbance (nausea, diarrhea, abdominal discomfort, metallic taste) No risk of hypoglycemia when used alone. In polycystic ovary syndrome may resume ovulation with metformin administration. Note: allergy to sulfonamide antibiotic is not absolute ci unless reaction is severe (involving organ damage) Lower risk of hypoglycemia compared to su. Decreased vitamin b12 (usually not clinically significant) Ci: t1d, excessive alcohol intake, severe hepatic dysfunction, severe renal impairment. Use glic and glim with caution b/w 30- Example initiation regimen: 500 mg bid for 3-5 days; then tid; then 1 g bid if necessary. Maintenance dose: 1. 5 g to 2 g per day; little additional benefit above 2 g. 30-44: 500mg bid (do not start therapy but may continue therapy) Elderly start with 50% of recommended dose to prevent hypoglycemia. If a meal is missed, the dose should be omitted.
