CAS BI 203 Lecture Notes - Lecture 18: Oligosaccharide, Proteome, Enzyme Replacement Therapy
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7 Dec 2017
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Question: what is the main function of the er: checking for proper protein folding via upr and erad. Within 10 minutes, proteins are in and out of the er and moving on to the golgi. Protein transit from er to final destination is mediated by vesicular transport. Vesicular transport entails four steps: orti(cid:374)g of (cid:862)(cid:272)argo(cid:863) i(cid:374)to a (cid:448)esi(cid:272)le (cid:271)ud, vesicle budding from the er exit site (eres, vesi(cid:272)le (cid:862)do(cid:272)ki(cid:374)g(cid:863) to target (cid:373)e(cid:373)(cid:271)ra(cid:374)e, vesicle fusion with target membrane. Ergic is the intermediate between the er =and the golgi apparatus. Proteins targeted for export have peptide and carbohydrate signals that direct their packaging into transport vesicles. Unmarked proteins in the er can also be packaged and transported to the golgi by a default pathway. Proteins that function within the er are recognized in the ergic or golgi and transported back to the er.
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