BIOL 031 Lecture Notes - Lecture 29: Toxic Heavy Metal, Tolbutamide, Hypoproteinemia
22 Dec 2020
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Causes for persistent proteinuria aka fixed proteinuria: Decreased tubular reabsorption of filtered protein tubular dysfunction. Overflow proteinuria increased infusions of albumin or blood fluid overload. Decreased kidney function ckd with decreased nephron mass. Histuria (i honestly don"t know what this is and dr. google was no help) Fixed proteinuria may or may not decrease serum protein levels and pretty much boils down to either glomerular or tubular dysfunction. It basically occurs because there is something wrong with the renal protein handling (any factor from question 2). Non-renal abnormalities: fever, stress, exercise, exposure to cold. False positives caused by: penicillin, sulfonamides, tolbutamide, radiologic contrast media. the mechanisms that mediate the findings of nephrosis. Hypoproteinemia (hypoalbuminemia): serum albumin < 2 gm/dl. Proteinuria is the initiating event to establish nephrosis. According to the lecturer, it pretty much happens because there is a change in the cytoskeletal structure of podocytes that lead to effacement of podocytes (flattening of podocytes).
