MCB 3020 Lecture Notes - Lecture 43: Rheumatic Fever, Antibody, Angioedema
Document Summary
Infectious triggers may cause sudden and massive release of highly potent pro-inflammatory cytokines (il-1, il-6 and tnf-alpha) Drives pathology linked to uncontrolled vascular leakage; neutrophil activation, fever, chills, coagulation, release of acute phase proteins, and septic shock. Persistent infection --> increased cytokine production --> cytokine storm and sepsis --> organ failure (severe sepsis) --> if it is still not resolved, you go into refractory hypotension --> septic shock --> Due to anti-bacterial treatment of infectious diseases caused by spirochetes. Mechanism is a rapid release of endotoxin-like product from dying bacteria due to abx treatment. Sx usually worsen within the first few hours of treatment or they can even be life threatening. Fever, chills, ha, myalgia, hypotension, flu-like sx, itch and rashes, flushes, etc. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. Appearance of neuropsych sx closely linked to group a beta-hemolytic streptococcal infections in children.
