BMD RES 5HA Lecture Notes - Lecture 4: Polyacrylamide Gel Electrophoresis, Antibody, Reducing Agent

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Rna sequencing tells you how many times an rna is made. When the cell undergoes starvation, the number of ribosomes decreases and the splicesosomes are now free to splice other things. She determined the amount of intron containing genes and comapared to the mrnas. The splicesomes are required to splice the introns. Snf2 has the ability to regulate rpgs and mer1 (only needed under starvation) It seems that snf2 knows when the cell is under starvation. This implies that there is a switch that tells snf2 that the cell is undergoing starvation. Big picture question - how can cells change their behavior based on a response to changes in the environment. Not all life has been able to adapt to changes in the environment. When the cell is stressed, does splicing have a role in the change of behavior/ environmental response. This is how she discovered for how introns are not always spliced our.

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