PHYSCI 121 Lecture Notes - Lecture 23: Monocyte, Muscle Tissue, Blood Vessel
Document Summary
Immune cells enter the muscle when damaged and envelope the muscle fibers. And what happens in the presence or absence of these cells. Removing the monocytes from the muscles by day 4, is similar with monocytes, by d7 there is no regeneration. Inflammation and regeneration is a positive thing: muscle tissue is interdependent with cells of the immune system. Today"s lecture will focus on the role of immune cells in acute muscle injury and repair. Mast cells in the tissue release histamine in the cell. The granules sit inside the mass cell ready to be released. Histamine causes blood vessel to swell and leak, purpose is to allow the immune cells into the tissue. Tumor necrosis factor increases expression of the cams: histamine=dilates vessels, increases leakiness. Tnf= increases expression of cell adhesion molecule (cam: cams facilitate leukocyte extravasation to muscle tissue. Tell immune cells to come in and signal to the immune system to allow entrance in the tissue.
