ANFS332 Lecture 11: Primary and Secondary Lymphoid Tissues, Antigen, Antibody Kinetics Clonal Selection
27 Feb 2018
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11:14 am: red text = important, blue text = do not need to know, toll like receptors. Dont memorize numbers (tlr4) but do know what they recognize (lps) Receptors (prr) will recognize a specific pamp (these are non specific) These are pathogens that are not found in the normal cell biology of the host o. Rois (reactive oxygen intermediates) and rnis (reactive nitrogen intermediates) - highly toxic to microorganisms are made. Cytokines and chemokines (small proteins which function as the chemical messengers of the immune response facilitating cell-cell communication) are produced (remember tnfa) Acute phase proteins (proteins synthesized largely in the liver and secreted rapidly following infection or tissue injury). o o o o o o o o. These are all non specific, general, innate immune responses. Innate immunity is critical to adaptive immune response. Adaptive immune response has to see specific elements of the disease to launch a specific response.
