Log in
HomeClass Notes1,200,000CA670,000

Biology 1002B Lecture Notes - Lecture 19: Tumor Suppressor Gene, Angiogenesis, Metastasis

11 views3 pages
School
Western University
Department
Biology
Course
Biology 1002B
Professor

For unlimited access to Class Notes, a Class+ subscription is required.

Document Summary

Maternal effect genes are packed in the mother and expressed there. The first gens to be transcribed in the nuclei of drosophila zygotes are the segmentation genes. Men are at a higher risk of cancer than women. War on cancer by the usa declared in 1971 but it didn t exponentially decrease the rate at which people were developing cancer; very slow given the effort invested in the cause. The difference in mortality rates due to cancer in canada could be due to demographics (more young people etc) or mutagens in a certain are or many other reasons. Heritability: what proportion of the phenotypic variability can we attribute to genetic variability. > heritability of cancer is kinda low (0. 27-0. 42) Cell fate: tumour cells are more embryonic; the cells of the tumour cell are less differentiated. Phase of rapid cell division, and then should be stopped as part of normal development.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents

Biology 1002B Lecture Notes - Lecture 19: Embryogenesis, Tumor Suppressor Gene, Microrna
amethystarmadillo903
Biology 1002B Lecture Notes - Lecture 17: Programmed Cell Death, Mental Floss, Histone Deacetylase
ultramarinecrab393
Biology 1002B Lecture Notes - Lecture 17: Helix-Turn-Helix, Programmed Cell Death, Breast Cancer
sapphirebear815

Related Questions

. We observed that cancer is the combination of variousmutations in individuals and that two people with the same cancertype can have very different mutations which cause it to occur.Which statement(s) below are TRUE?

A. Cancer is caused by multiple “hits” or mutations.

B. All cancers are caused by a mutation in TP53.

C. Cancer can be caused by multiple mutations in processesregulating mitosis.

D. Cancers can be caused by chromosomal changes (deletions,insertions, viruses) as well as small point mutations.

E. Cancer is the leading cause of death in the UnitedStates.

F. Exposure to mutation-inducing chemicals (mutagens) increasesthe number of “hits” a person might have and thus increase theirrisk of cancer.

G. Cancer can be caused by multiple mutations in processesregulating cellular differentiation (growth and maturity).

H. Cancer can be caused by chromosomal maintenance mutations(telomere shortening, epigenetic changes, DNA Polymerase defects,etc.)

I. Cancer can be caused by mutations that increase cell deathpathways.

J. Cancer can be caused by mutations that decrease cell deathpathways. K. Checks and balances in multiple pathways ensure thatone mutation does not cause cancer to develop in humans.

A hypothetical observational breast cancer study enrolled 10,000 women age 50 and older during 1990 and followed each woman for 10 years. All women received a free medical exam, including a mammogram, at baseline and each year thereafter. All deaths were full investigated and there was no loss to follow-up. At the baseline examination, 80 women were diagnosed with having early breast cancer. Twenty of these women died during the 10 year follow-up. By the end of follow-up, 240 other women had developed breast cancer, including 30 who died from their disease. Two hundred other women (who did not develop breast cancer) died from other causes.

a. What was the prevalence of diagnosed early breast cancer in the study population at baseline?

b. What was the 10-year case-fatality “rate” in women with early breast cancer at baseline?

c. What was the cumulative incidence of breast cancer during the 10 year follow-up?

d. What was the incidence rate (incidence density) of breast cancer in the study population during the 10 year follow-up?

e. What was the breast cancer mortality rate in the study population during the 10 years?

f. What was the all-cause mortality rate in the study population during the 10 years?

g. What was the proportionate mortality for breast cancer?

h. What was the prevalence of (diagnosed) breast cancer in 2000?

These questions were previously asked but my Professor wasunsatisfied so I'm trying again to see if anyone is able to do agood job and get me some points.


The global community is plagued by increasing incidence oflung cancer, colorectal cancer, breast and pancreatic cancers,prostate cancer, leukemia, non-Hodgkin lymphoma, liver, ovarian andesophageal cancers. Other types of cancer exist but are lessfrequent. What is the scientific community doing to attempt toeliminate the most common forms of cancer that are ravaging oursociety?

1. Be certain you