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16 Jul 2018

What analogy could be drawn from the process of extracellular epidermal growth factor (EGF) signal transducing into changes in gene activity inside the nucleus? Please be specific

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Trinidad Tremblay
Trinidad TremblayLv2
18 Jul 2018

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Related questions

Can someone please help me with the 2 questions below! I'm notunderstanding at all and can you explain how you got your answer soI can understand. Thank you in advance! :)

  1. Epidermal Growth Factor is a protein that binds its receptorwith high affinity (low Kd). Choose the most likely order of eventsfor what ensues:
  • A) G protein activation> tyrosine kinase activity>transcription factors active> map kinase activation and signalamplification
  • B) G protein activation and signal amplification > mapkinase activation >transcription factors active>tyrosinekinase activity
  • C) tyrosine kinase activity>G protein activation> mapkinase activation and signal amplification>transcription factorsactive
  • D) tyrosine kinase activity>Gprotein activation> phosphatase activation> secondmessengers>map kinase activation >transcription factorsactive

2. Epidermal Growth Factor (EGF) levels eventually dissipate andthe cellular response (gene transcription and translation) stops.Which of the following is not a possible reason for a cancer cellto have an inappropriate EGF pathway response:

A) mutation in an EGF receptor gene

B) mutation in a ras gene

C) mutation in a gene coding for a kinase

D) mutation in a gene coding for a second messenger

Running out of questions for this period, so please help me answer these! :)

1. Substitution with which of the following amino acids would generate an effect that is similar to phosphorylation?
A. Glutamic Acid (E)

B. Lysine (K)

C. Serine (S)
D. Alanine (A)

2. Which of the following structures is most dramatically altered by the hydrolysis of its bound nucleotides?
A. Microtubules

B. The centrosome

C. Actin Filaments

D. Nuclear Lamin

3. In EGF (epidermal growth factor) signaling, which molecule connects with extracellular signal to the cytoplasm?
A. The EGF hormone

B. The EGF receptor

C. Grb2

D. ERK

Select the correct order of events (1-10) for the signal transducon pathway iniated by the EGF receptor. (place the number 11 for those which are not applicable).

_____ MEK is phosphorylated by RAF.
____ The receptor undergoes a conformaonal change.
_____ The second messengers IP3 and DAG are produced.

_____ The cytoplasmic tail of the receptor is phosphorylated.

_____ An adaptor protein binds to the phosphotyrosine residues, recruing SOS and Ras.

_____ MEK is phosphorylated by ERK.

_____ RasGAP stimulates GTPase activity of Ras which returns to the GDP bound state.

_____ ERK is phosphorylated by MEK.

_____ The Galpha subunit dissociates from Gbeta/Ggamma.

_____ ERK enters the nucleus and smulates cell proliferaon.

_____ The receptor dimerizes acvang its tyrosine kinase acvity.

_____ The Galpha subunit binds to Phospholipase C.

____ Epidermal growth factor binds to the receptor.

_____ Ras is phosphorylated by RAF.
____ The Galpha protein releases GDP and binds GTP.

____Glucagon binds to the receptor.

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