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Describe expanding trinucleotide repeats and how their presencein coding regions of a gene can lead to an inactive protein.

What is alternative splicing? What might be an adaptive featureof alternative splicing?

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Jamar Ferry
Jamar FerryLv2
28 Sep 2019

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Related questions

Which of the following statements about splicing is false?

A. a single gene can code for many types of protein due to alternative splicing

B. The 5' and 3' regions of the intron are highly variable in sequence

C. the spliceosome is found in the nucleus of the cell

D. The mRNA is composed of exons; introns are spliced out

Explain how a eukaryotic gene with a single promoter and one intron would have its pre-mRNA processed. If alternative splicing lead to intron-skipping, how would the protein be altered after the translation of the mRNA?

A. To make an mRNA transcript from a gene, the RNA polymerase needs to 'know' where to start and to stop. What are the signals and proteins involved in initiating and terminating RNA polymerase activity in E. coli?

B. Alternative splicing is a key feature of the eukaryotic transcription-translation process.

i) In eukaryotes, alternative splicing of pre-mRNAs can result in the production of many structurally distinct proteins from information encoded in a single gene. Explain.

ii) Do lower eukaryotes (such as yeast, Saccharomyces cerevisiae) have the same opportunity to use alternative splicing to generate a vast array of proteins from a single gene? Explain.

iii) What other splicing events can lead to additional diversity in the repertoire of proteins that could be encoded by a single gene? Hint: think of the N and C terminal ends. What about a post-translational mechanism. Name one.

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