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Which of the following statements about splicing is false?

A. a single gene can code for many types of protein due to alternative splicing

B. The 5' and 3' regions of the intron are highly variable in sequence

C. the spliceosome is found in the nucleus of the cell

D. The mRNA is composed of exons; introns are spliced out

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Keith Leannon
Keith LeannonLv2
28 Sep 2019
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Related questions

QUESTION 1

Which of the following statements regarding splicing is FALSE?

A) The length of introns determines the efficiency of splicing.

B) Many human neurological disorders are caused by splicing errors and/or mutations in splicing factors.

C) Splicing requires the action of a variety of snRNAs that direct the transesterification reactions.

D) Splicing is dictated by sequence features in pre-mRNA transcripts

QUESTION 2

Which of the following mRNA processing factors does NOT associate with the CTD of RNA polymerase II?

A) splicing factors

B) polyadenylation factors

C) miRNAs/siRNAs

D) capping proteins

QUESTION 3

Which of the following statements about mRNA stability is FALSE?

A) Deadenylation-independent mRNA decay is exclusively in the 5' to 3' direction.

B) The most common pathway of mRNA decay is deadenylation-dependent.

C) Yeast mRNA decay occurs primarily in the 5' to 3' direction, while 3' to 5' decay is more common in mammalian cells.

D) Decapping enzymes are required for all pathways of mRNA decay.

QUESTION 4

You obtain the sequence of a gene containing 10 exons, 9 introns, and a 3′ UTR containing a polyadenylation consensus sequence. The fifth exon also contains a polyadenylation site. To test whether both polyadenylation sites are used, you isolate mRNA and find a longer transcript from muscle tissue and a shorter transcript from all other tissues. Which of the following is the most likely mechanism underlying these alternative transcripts?

A) The fifth exon is spliced out of the mature mRNA transcript in muscle cells.

B) Muscle cells have less effective polyadenylation than other tissues.

C) An alternative CPSF protein is expressed in muscle cells with lower affinity for the polyadenylation sequence in exon 5.

D) The mRNA in muscle cells is edited to eliminate the polyadenylation sequence in exon 5.

QUESTION 5

The RNA component and not the proteins, of the RNA splicing machinery is responsible for splicing mRNA.

True

False

10 points

QUESTION 6

Which of the following is FALSE regarding Alternative Splicing? (Choose ALL that apply)

A.

Alternative splicing occurs at extremely high levels in nervous tissue.
B.

Alternative splicing alternates involves the inclusion of different exons within a given gene.
C.

Alternative splicing involves the inclusion of different introns within a given gene.
D.

Alternative splicing allow for multiple mRNA transcripts to be expressed from one gene

10 points

QUESTION 7

Which of the following is FALSE regarding Dissociator? (Choose the one correct answer.)

A.

Movement of Dissociator only occurs during early development.
B.

It is a transposable genetic element.
C.

It 's presence within a color gene disrupts pigment production.
D.

It's movement is controlled by a second element called 'Activator'.

10 points

QUESTION 8

An antigen can be a protein, nucleic acid, or a polysaccharide.

True

False

10 points

QUESTION 9

Which of the following statements is TRUE regarding the cell cycle? Choose ALL that APPLY.

A.

CDKs are downregulated by cyclins.
B.

Mature, differentiated cells exit the cell cycle into a resting phase called G0.
C.

DNA damage that occurs after the Restriction Point will not arrest the cell cycle since the cell has passed the 'point of no return'.
D.

CDKs are activated by CKIs

10 points

QUESTION 10

Homeotic genes display spacial colinearity.

True

False

Q.1

A gene has two introns and three exons. The length of exons 1, 2 and 3 is 600, 1200 and 300 bp, respectively, which are separated by 400 bp intron-1 and 800 bp intron-2. Suppose, a mixture of the dsDNA completely covering this gene and the processed mRNA it codes for is heated at 95C for 10 minutes, gradually cooled to room temperature and then viewed under electron microscope (EM). Draw the diagram of the DNA-RNA hybrid that you expect to see under the EM and answer the following questions. You should use different color for DNA and RNA strands , and label the regions that represent dsDNA, ssDNA and RNA-DNA hybrid. The diagram must take into account the length of introns and exons.

Q.2

What is the function of SR and silencer proteins that activates and represses splicing, respectively? Name the domains that are found in these proteins and explain their function. Explain how the splicing silencer proteins inhibit the function of the SR proteins.

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