1. Neurofibromatosis is inherited as a dominant gene. If a young child is the first in her family to be diagnosed (the proband), and the disease has a full penetrance in the corresponding population, which of the following is correct?
A. The mother is the carrier of the allele
B. The mutation has occured in gametogenesis of one of the parents
C. The condition will skip some generations in the family
D. The child will certainly have normal siblings with the abnormal genotype.
E. Both parents cannot be free from the disorder- one of them will certainly display the symptoms later in life.
F. Either infidelity is involved, or the child is not the biological offspring of her parents.
2. A man who suffers from a Y-linked disease marries a normal woman who has a red-green color blind (XLR) maternal grandfather. What is the chance that the couple will have a child affected with both conditions?
A. Zero
B. 25%
C. 50%
D. 12.5%
E. 100%
1. Neurofibromatosis is inherited as a dominant gene. If a young child is the first in her family to be diagnosed (the proband), and the disease has a full penetrance in the corresponding population, which of the following is correct?
A. The mother is the carrier of the allele
B. The mutation has occured in gametogenesis of one of the parents
C. The condition will skip some generations in the family
| D. | The child will certainly have normal siblings with the abnormal genotype. | ||||||||||||||||
| E. | Both parents cannot be free from the disorder- one of them will certainly display the symptoms later in life. | ||||||||||||||||
| F. Either infidelity is involved, or the child is not the biological offspring of her parents. 2. A man who suffers from a Y-linked disease marries a normal woman who has a red-green color blind (XLR) maternal grandfather. What is the chance that the couple will have a child affected with both conditions?
|
