A typical glycogen particle contains 50,000 glucose residues and has 2,000 non-reducing ends. Recall that the degradation of glycogen involves the action of glycogen phosphorylase, which releases glucose 1-P, and glycogen debranching enzyme, which releases glucose.
A - Approximately how many ATPâs are produced from the complete catabolism of one glycogen particle?
B - The addition of one glucose residue onto the nonreducing end of a glycogen strand requires six enzymes: hexokinase; phosphoglucomutase; UDP-glucose pyrophosphorylase; inorganic pyrophosphatase; glycogen synthase; and nucleoside diphosphate kinase. By considering the net reaction catalyzed by the sequential action of these enzymes, determine how many ATPâs are required to add one glucose molecule onto glycogen, and from that, how many ATPâs are required to synthesize an entire glycogen particle.
C - Given that 31 ATP molecules are produced from each glucose 6-P through oxidative phosphorylation, compare the cost of production of a glycogen particle and the energy obtained by its complete oxidation to calculate the efficiency of storing glucose in glycogen. The efficiency can be considered to be (net ATP gained)/(total ATP gained).
A typical glycogen particle contains 50,000 glucose residues and has 2,000 non-reducing ends. Recall that the degradation of glycogen involves the action of glycogen phosphorylase, which releases glucose 1-P, and glycogen debranching enzyme, which releases glucose.
A - Approximately how many ATPâs are produced from the complete catabolism of one glycogen particle?
B - The addition of one glucose residue onto the nonreducing end of a glycogen strand requires six enzymes: hexokinase; phosphoglucomutase; UDP-glucose pyrophosphorylase; inorganic pyrophosphatase; glycogen synthase; and nucleoside diphosphate kinase. By considering the net reaction catalyzed by the sequential action of these enzymes, determine how many ATPâs are required to add one glucose molecule onto glycogen, and from that, how many ATPâs are required to synthesize an entire glycogen particle.
C - Given that 31 ATP molecules are produced from each glucose 6-P through oxidative phosphorylation, compare the cost of production of a glycogen particle and the energy obtained by its complete oxidation to calculate the efficiency of storing glucose in glycogen. The efficiency can be considered to be (net ATP gained)/(total ATP gained).
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