Microbiology and Immunology 3300B Study Guide - Final Guide: Phagocytosis, Mannose, Tlr9
29 Mar 2013
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Document Summary
Post-capillary venules that come after capillaries; slow movement of rbc. Detection: there are two ways to detect damage; the first is through different receptors. Mitochondria produce formyl peptides that bind fmlp receptors, and also have cpg dna that binds tlr 9. There are metabolites produced by pathogens in the ic areas such as heat shock protein and hmg, as well as metabolites such as uric acid and atp. Activation of resident immune cells: macrophages take up the antigens and produce chemokines or cytokines after this occurs there are multiple different effects. Leukocyte recruitment: p-selectin binds sialyl lewis on the leukocyte causes rolling (slow movement). Systemic response: acute phase response: il1 beta, il6 and tnf alpha produce the responses. In acute phase response macrophage binds bacteria and produces il6 which causes hepatocytes in the liver to make acute phase proteins to opsonize: mannose binding lectins, sp a/d, c-reactive proteins, serum amyloid proteins (c-reactive binds phosphocholine).
