LMP299Y1 Lecture Notes - Tumor Suppressor Gene, Receptor Tyrosine Kinase, G1 Phase
3 Jun 2013
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Cancer genetics molecular bases march 26. Determination of cell needs to prolifeate and divide. Signal transduction crucial to all cells a number of ways to stimulate cells to grow. Signal transduction relay message through cell received on surface of cell send signal to nucleus theme for many pathways. If not growth factors available or receipient ligands no message relayed. Can lead to cancer in different organs depend on where expressed. Players that can act in others one such is myc (important!) If can get to nucleus and drive the program that says to proliferate without having received external signal. Abl gene not receptor tyrosine kinase. Examples of genes that when mutated, act as onocogenes so promote development and progression of cancer*********** G1 phase at this point where the cell is still receving signal from outside but pass this point, cell will make decision to divide regardless of external cues.
