BIOL130 Lecture Notes - Dna Replication, Sarcoma, Apoptosis

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Unit 10/11 cells in their social context. Cytoskeleton consisting of microtubules, intermediate filaments, Microfilaments: a network of fibres forming scaffolding" within the cytoplasm, determines cell shape, position of organelles, allows movement of organelles/component within cells. Coordinates movement of chromosomes during mitosis: allows movement of the cells themselves ( motility") forms flagella, cilia, lamellipodia, cytoskeleton is dynamic > constantly being reorganized (serves as both bones" and muscles" of the cell) Keratins the most diverse class of intermediate filaments: every type of epithelium in the body has its own mixture of keratin protein (gut lining, skin, tongue, cornea, skin produces many types of keratin. Secreted filaments can form fingernails, hair, hooves, horns. Microtubules: hollow tubes of tubulin, roles of microtubules: Stable form cilia, flagella: dynamic microtubules. Crucial organizing role in all eukaryotic cells. Movement of chrms during mitosis (mitotic spindle) Form system of tracks" for movement of vesicles/organelles: microtubules provide rails motor proteins provide engines.

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