IMM250H1 Lecture : Lecture note

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redtermite204

21 Jan 2012

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Midterm two is not cumulative 40 m/c questions type 1 and type 2 questions. If long term prime b cells their activation require linked recognition and this lr ws mhc restricted. What b cells reconizes needs to be pysically associated with what t cells recognize. B cell will indirectly using hapten carrier system, will indirectly acquire. Bystander b cell response non-specific immunoglobulin response not because unspecific but do not know specificity, that s the reason. T cells will enventually interact with professional apc that has acquired dnp carrier, chops it up, expresses determinants derived from carrier in context of mhc class 2 it expresses. Resting t helper cell wil linteract with professional antigen cell e xpressing carrier peptides becomes acivates. B cells pick up dnp covanelty linked to carrier will pick up dnap because specific for dnp. And because of covalent link will pick up carrier thus must have carrier function.

Related Questions

1. Nonspecific defenses usually come into play before the body's specific defense system is relied upon. Which of following nonspecific defenses is mismatched?

a. inflammation-- reddening, swelling, and tissue repair

b. fever-- elevation of body temperature to kill invading agents

c. mucus production-- allows B-cells to maneuver within mucus and secrete antibodies

d. complement-- inflammation and lysis of pathogen

e. physical barriers-- skin and mucous membranes

2. Circulating immunoglobulins (antibodies) are synthesized by this class of cells.

a. T-lymphocytes

b. bone marrow stem cells

c. neutrophils

d. activated B- cells

e. none of the above

maroonrhinoceros193

Host Defenses Activity

Our ability to fight off infection is three fold. Below is a list of terms that deal with our defenses. Match the definition with the terms on this sheet and then fill in the attached diagram with the terms below.

Host Defenses

1st Line of defense ___G_
2nd line of defense ____
3rd line of defense ____
Innate, nonspecific immunity____
Acquired, specific immunity____
T lymphocytes____
Complement____
Physical barriers____
Phagocytosis____
Chemical barriers____
Inflammatory response____
Fever____
B lymphocytes _____

Matching Definitions

A. immunity present at birth, provide nonspecific resistance to infection
B. Adaptive immunities: Immunity that develops after the interaction of antigens with the immune system
C. Many different types, involved in cell-to-cell contact or CMI
D. barrier that blocks invasion at the portal of entry
E. Protective cells and fluids; inflammation and phagocytosis
F .Acquired with exposure to foreign substance; produces protective antibodies and creates memory cells
G. Skin and mucus membranes
H. Bile, stomach acid, skin pH, lysozyme
I. Surveys tissue and discover microbes and dead or injured cells and removes them
J. 26 blood proteins that work to destroy bacteria and viruses
K. Rubor, tumor, calor, dolor
L. Initiated by circulating pyrogens which reset the hypothalamus to inhibit the growth of microbes
M. Responsible for AMI and production of antibodies

Which of the following is false regarding MHC molecules?

	A.	Professional antigen-presenting cells are the only cells in the body that express class II MHC molecules
	B.	The vertebrate MHC locus encodes multiple class I and class II MHC genes as well as components of the complement cascade and the antigen-processing machinery
	C.	Class I MHC molecules are present on most, if not all, nucleated cell membranes
	D.	T cells specifically and exclusively recognize antigen in complex with class II MHC

IMM250H1 Lecture : Lecture note

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