Microbiology and Immunology 3300B Lecture : Immunology Notes
20 Feb 2012
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The tcr has many similarities to the bcr/ab and looks like a fab fragment. It has and chains each with two ig domains, v and c regions, and cdr1, cdr2, and cdr3 in the v region. Signalling is mediated through a molecular complex that includes cd3 (contains two domains, one domain, and one domain) and a chain with itam on them. Cdr1 and cdr2 are found in the periphery and recognize mhc. Cdr3 is highly variable and is found in the centre of the tcr and interacts with antigen. Tcr/peptide/mhc binding: involves a large complex of molecules. Tcr bind to peptide/mhc complexes on the surface of antigen-presenting cells. This leads to the recruitment of lck which phosphorylates the itams on cd3 and in the tcr. Zap-70 binds to phosphorylated itams through its sh2 domain, which causes it to be phosphorylated by lck.
