Biology 1002B Lecture Notes - Lecture 18: Helicase, Dna Replication, Primase

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Dna (information) is relatively stable and readily replicated. Anti-parallel complementary base pairing allows for accurate replication. Replication is semi-discontinuous and semi-conservative: one strand is replicated continuously and the other discontinuously, at the end of replication there is always an old strand and a new strand. Prokaryotes have a single origin and replication forks in either direction: mitochondria and chloroplasts replicate like prokaryotes (bacteria) Replication bubble arises from two forks created at one origin: organelle genomes, prokaryote genomes. Both strands are replicated in the same replizone at the same time very close together. The primer that was close to the replisome is now quite far away and a new primer is added, we primed a new bit of synthesis. This polymerase is going to smash into this previously produced primer and the primer will have to be removed. The top strand is replicated continuously and the bottom strand is replicated discontinuously.

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