CSB331H1 Study Guide - Midterm Guide: Pdz Domain, Adherens Junction, Cell Junction

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coraleel39

7 Sep 2012

School

UTSG

Department

Cell and Systems Biology

Course

CSB331H1

Professor

Katherine Sodek

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Document Summary

Epithelial tissue mechanical stress transmitted from cell to cell across the whole epithelia by cytoskeletal filaments anchored to cell-matrix and cell-cell adhesion sites. Connective tissue extracellular matrix directly bears mechanical stress of tension and compression. Occluding junctions: tight junctions regulate what can pass through epithelia. Cell-cell anchoring junctions: adherens junctions link actin filaments between cells, desmosomal junctions link intermediate filaments between cells. Integrins anchor actin filaments: hemidesmosomes anchor intermediate filaments. Light microscopy cannot resolve details smaller than its own wavelength. Cell-cell junctions can be visualized with electron microscopy: use biochemical and molecular biology methods to study function. Adherens junctions connects actin filament bundle in one cell with that in the next cell. Cadherin (classical cadherin) is the transmembrane adhesion protein that mediates adherens junctions: e-cadherin (many epithelia, n-cadherin (neurons, heart, skeletal, muscle, fibroblasts, p-cadherin (placenta, epidermis, breast epithelium, ve-cadherin (endothelial cells) E-cadherin expression confers the polarized epithelial phenotype: loss of e-cadherin = emt, gain of e-cadherin = met.

Related Questions

1. How does the extracellular matrix affect a cell that it surrounds? (Select all that apply.)

		The cell's shape depends in part on the structure and composition of the extracellular matrix.
		The genes that the cell expresses depend in part on the types of proteins in the extracellular matrix.
		The size that the cell grows to depends in part on the polysaccharides in the extracellular matrix.
		The extracellular matrix has no effect on the cells that it surrounds.
		All of these choices are correct.

2. Dynamic instability is the rapid assembly and disassembly of:

		microfilaments.
		intermediate filaments.
		microtubules.

3. Which one of the following is a characteristic shared by integrins and cadherins?

		Both are peripheral membrane proteins.

		Both are present in adherens junctions, desmosomes, and hemidesmosomes.
		The cytoplasmic domains of both proteins are connected to the cytoskeleton.

4. Which of the following is a mesh-like attachment between cells formed by binding of transmembrane proteins of one cell to the same protein type on the adjacent cell, preventing substances from passing between cells?

		a.) adherens junction
		b.)desmosome

		c.) tight junction

viridianlion889

1. How does the extracellular matrix affect a cell that it surrounds? (Select all that apply.)

	The cell's shape depends in part on the structure and composition of the extracellular matrix.
	The genes that the cell expresses depend in part on the types of proteins in the extracellular matrix.
	The size that the cell grows to depends in part on the polysaccharides in the extracellular matrix.
	The extracellular matrix has no effect on the cells that it surrounds.
	All of these choices are correct.

2. Which of the following enable(s) the movement of cells?

	microtubules
	microfilaments
	intermediate filaments
	microtubules and microfilaments
	microfilaments and intermediate filaments

3. Microtubules increase in length:

	more quickly at one end than the other.
	by growing outward from the centrosome.
	in cycles, following rapid depolymerization.
	if free tubulin dimers are available.
	All of these choices are correct.

4. Dynamic instability is the rapid assembly and disassembly of:

	microfilaments.
	intermediate filaments.
	microtubules.
	both microfilaments and microtubules.

5. Which one of the following is a characteristic shared by integrins and cadherins?

	Both are peripheral membrane proteins.
	Both facilitate the adhesion of cells to extracellular matrix proteins.
	Both are present in adherens junctions, desmosomes, and hemidesmosomes.
	The cytoplasmic domains of both proteins are connected to the cytoskeleton.

6. Cadherin is an example of a(n):

	motor protein.
	intermediate filament protein.
	cell adhesion molecule.
	extracellular matrix protein.

7. Which is the CORRECT order from lesser to greater complexity for the following?

	organs, tissues, cells
	cells, tissues, organs
	tissues, organs, cells
	cells, organs, tissues

pucebear535

Match each description or phrase with the correct cytoskeletal structure. Note that a cell type can be used more than once or not at all.

cellular contractions

intermediate filaments All cytoskeletal structures microtubule microfilaments None of these

flagellum movement

intermediate filaments All cytoskeletal structures microtubule microfilaments None of these

anchoring one cell to another

intermediate filaments All cytoskeletal structures microtubule microfilaments None of these

maintain cell shape

intermediate filaments All cytoskeletal structures microtubule microfilaments None of these

CSB331H1 Study Guide - Midterm Guide: Pdz Domain, Adherens Junction, Cell Junction

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