PHAR 300 Final: Anaesthesia
10 Jan 2019
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Document Summary
Relax patient, abolish pain, reduce saliva and mucus formation. Reverse muscle relaxation: to not wake up paralyzed. October 16th, 1846: first general anaesthesia in boston with diethyl ether (disadvantage: highly flammable) Injection, inhalation, determined by machine (blood gas monitor, gas regulator, ekg and blood pressure) Strategy is to inject a cocktail of drugs: Combine different agents to increase effectiveness and safety. Use smaller amounts of different drugs to maximize safety. Ans depressant (less seen in iv route of administration) Context-specific half-life: will build up in tissue, so the longer you administer the longer the time to clearance. Small margin of safety and knock out crucial brain functions. Leads to alpha waves, then to fast activity, then rhythmic, then complex, burst suppression (early and late) and finally, suppression of activity. Can have multiple actions: increase inhibitory, decrease excitation. Extrasynaptic receptors though to be part of memory- impairing function. Cortex is highly susceptible and falls unconscious first.
