PAT 20A/B Study Guide - Final Guide: Insulin Receptor, Insulin Resistance, Beta Cell
5 Jan 2017
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Document Summary
Presence of hyperglycemia in association with relative insulin. Cause deficiency: not the autoimmune destruction of beta. Impaired beta cell functioning resulting in decreased insulin production. Increased hepatic glucose production: decreased peripheral utilization of glucose, decreased utilization of ingested carbohydrates. Mody ( maturity-onset diabetes of the young: a subtype of diabetes in which the disease is transmitted in an autosomal dominant pattern, occurs at an earlier age ( usually before 25 years of age) People may have high, normal, or low insulin levels ( Less prone to ketoacidosis : b/c they do not have an absolute insulin deficiency, remember: no insulin= more fatty acid breakdown/being converted into ketones. The efficiency at which the glucose clearance occurs is breakdown) diminished resulting in an increase in post prandial blood glucose levels. Visceral adipocytes release an excess amount of free fatty acids associated with insulin resistance. Several adipocytokines cause insulin resistance in the muscle.
