PAT 20A/B Study Guide - Final Guide: Insulin Receptor, Adipose Tissue, Pioglitazone
5 Jan 2017
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Document Summary
Hepatic glucose production by reducing gluconeogenesis. Improves insulin receptor sensitivity in the liver, skeletal muscle, and adipose tissue resulting in increased glucose uptake by these organs. Overal effect increased peripheral glucose uptake: decreased liver production of triglycerides & cholesterol. Act to insulin resistance by the sensitivity of insulin receptors in the liver, skeletal muscle, and adipose tissues. These drugs are known to directly stimulate glucose and triglyceride production in the liver. They have no known effect on insulin secretion. Opening ca+ increases insulin release: this increased insulin helps transport the glucose out of the blood and into the tissues, cells, and organs in which it is needed. Increases the uptake of glucose by these organs. Increase the availability of insulin by preventing the liver from breaking down as fast as it normally would. Overall effect they improve both insulin secretion & the sensitivity to insulin in tissues.
