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CHMB62H3 (4)

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University of Toronto Scarborough
John Glover

Chapter 5 1 Partners What does an apoenzyme require to become a holoenzyme 2 Different partners What are the two main types of cofactors 3 One a day Why are vitamins necessary for good health4 A function of state What is the fundamental mechanismby which enzymes enhance the rate of chemical reactions 5 Nooks and crannies What is the structural basis for enzyme specificity 6 Give with one hand take with the other Why does the activation energy of a reaction not appear in the finalG of the reaction 7 Mountain climbing Proteins are thermodynamically unstable TheG of the hydrolysis of proteins is quite neg ative yet proteins can be quite stable Explain this apparent paradox What does it tell you about protein synthesis 8 Protection Suggest why the enzyme lysozyme which degrades cell walls of some bacteria is present in tears 9 Stability matters Transitionstate analogs which can be used as enzyme inhibitors and to generate catalytic antibod ies are often difficult to synthesize Suggest a reason 10 Matchem Match the Kvalues with the appropriateG values eq KG eq1 2858 510 1142 410569210 0 110 2284 11 Free energy Assume that you have a solution of 01 M glucose 6phosphate To this solution you add the enzyme phosphoglucomutase which catalyzes the reactionGlucose 6phosphateglucose 1phosphate 1 1TheG for the reaction is 75 kJ mol18 kcal mol a Does the reaction proceed as written and if so what are the final concentrations of glucose 6phosphate and glucose 1phosphate b b Under what cellular conditions could you produce glu cose 1phosphate at a high rate 12 Free energy too Consider the following reactionGlucose 1phosphateglucose 6phosphate After 1 M of reactant and product were mixed and allowed to reach equilibrium at 25C the concentration of each compound was measured Glucose 1phosphate 001 M eq Glucose 6phosphate 019 M Calculateeq KandG eq 13 FreeenergyyetagainTheisomerizationofdihydroxy acetone DHAP to glyceroldehyde 3phosphate GAP has an equilibrium constant of 00475 under standard calcula tions 298 K pH 7 CalculateG for the isomerization Next calculateG for this 4 reaction when the initial concen tration of DHAP is 2 X 10M and the 6 initial concentration of GAP is 3 X 10M What do these values tell you about the importance ofG compared with that ofG in under standing the thermodynamics of intracellular reactions 14 Potential donors and acceptors The hormone proges terone contains two ketone groups At pH 7 which side chains of the receptor
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