BIO130H1 Study Guide - Final Guide: Intraflagellar Transport, Cycloheximide, Intermediate Filament

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12 Jul 2017
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BIO130H1 Full Course Notes
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Cytoskeleton made up of complex network of filaments (microtubules, microfilaments, intermediate filaments) Allow cells to transport materials intracellularly, change shape, interact mechanically with environment, move within environment. Microtubules: long, hollow protein cylinders built from tubulin dimers (repeating structural units) Tubulin dimer: comprised of 1 (cid:2009)-tubulin and 1 (cid:2010)-tubulin protein bound together by noncovalent interactions, Arrangement of (cid:2009)-tubulin and (cid:2010)-tubulin proteins results in structural polarity of microtubule; 1 end (plus end) interact with head-to-tail polarity different from other (minus end) Differing growth rates, 1 end has much faster net growth than other. Microtubule constantly growing and shrinking, plus end performs both activities at faster rate than minus end. Dynamic activity of microtubules permits cell to control and modify structure of cytoskeleton by disassembling and reassembling microtubules. Cell recycles tubulin dimers (treadmilling: dimers added to + end as others lost from - end of same filament)

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