IMM250H1 Study Guide - Final Guide: Nadph Oxidase, Metabolite, Cytokine Storm
Document Summary
Multimeric proteins bind to sugars on cell surface. Myd-88 binds (or trif binds) nf b (or irf) transcription factors cytokine & interferon. Detected by nlrp (in the nlr family) Contains a pyrin domain that interact with asc adaptor. Christianne volhard discovers toll protein in fly embryo for dorsal/ventral control. Nicholas gay discovers il-1 has similar intracellular domain to toll. Lemaitre & hoffman discovers toll deficient die from aspergilius. Janeway & medzhitov discovers human toll (htoll tlr-4) Rock & bazan discovers many proteins similar to toll (tlr) Beutler tlr4 activated by lps; rat experiment. Inside vacuole, salmonella inject cells with proteins to prevent detection & begins to divide. Attacks the epithelial cells from basal pole. Uses actin filaments of cell to allow motion inside cytoplasm. Affected by: genetics; lifestyle & diet ;early life colonization; drug use. Microbiota that moves out from normal location can cause immune response. Virulence factors gained by normal microbiota can lead to disease.
