IMM250H1 Study Guide - Klh (Company), Innate Immune System, Adaptive Immune System

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16 Nov 2012
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Jenner originally used cowpox to vaccinate people against smallpox. Eventually it was found that in vaccinated animals there was a blood component that stuck to the component vaccinated against. All blood cells and white blood cells (leukocytes) from pluripotent hematopoietic stem cells in the bone marrow o o o o. Upon exposure to antigen in tissue; will engulf and display antigen. Moves into lymph nodes to interact with adaptive immune system o. Lymphocytes: around same size as red blood cell and circulate in blood. Releases lytic granules that kill some virus-infected cells. Germinal centers (yellow) where b cells undergo rapid proliferation. Medullary cords (red) contains macrophages and plasma cells. Central arteriole (red) surrounded by periarteriolar lymphoid sheath ( blue) Marginal zone also for b cells with different functions o. Peyer"s patches covered by gut epithelia with specialized m cell. Lymphatic systems joins blood circulation at point of least blood pressure. Some cells migrate from blood to lymph node.

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