PCL201H1- Final Exam Guide - Comprehensive Notes for the exam ( 72 pages long!)

• School: UTSG
• Department: Pharmacology and Toxicology
• Course: PCL201H1
• Professor: Michelle Arnot

Document Summary

Digitalis: foxglove plant, digitoxin and digoxin, treat cardiac arrhythmias. Morphine: opium poppy, analgesic, precursor to semi and synthetic opiates. Salicin: willow bark, headache, pain, fever, salicylic acid later puri ed (active metabolite) 19th century: rudolf buchheim: rst professor of pharmacology, schwmiedeberg: founder of modern pharmacology. 20th century: langley and ehrlich proposed receptor theory, clark introduced model, ach, oxytocin, histamine, penicillin, insulin, streptomycin all isolated, insulin: banting and best, 1922, toronto, 1200 new drugs approved between 1950-2008. Industry: 1000 prescription drugs marketed, 4 billion prescriptions/year us, 100$ billion in research, 643$ billion spent on drugs. Drug names: generations, generic name is generally used (acetominophen, ibuprofen, trade name is brand name (tylenol, advil, first generic has 180 days market exclusivity. Pharmacotherapy treatments: antidepressants: increase da, anticonvulsants: decrease da, patch, methadone: replacement, vaccination. Pharmacokinetics: determine time course for drug after administration, linked to pd by plasma concentration. Safety: td50: toxic dose for 50% population, ti = td50/ed50.