Microbiology and Immunology 3300B Study Guide - Final Guide: Adaptive Immune System, Cancer Immunology, Gut Flora
1 Jun 2013
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L20: immunity to infectious diseases: p. 9. 29-9. 31, 13. 1-13. 6. Humans+pathogens co-evolved: successfully(jc virus) vs. no co-evoution(ebola) Virus wouldn"t want to kill host because that means it dies too. Balance b/w host+path: host:min loss of fitness select successful mhc haplotypes, res genes+less-virulent path strain path: max repro success host survival at least until transmitted elsewhere, avoid immunity, modulation of virulence) Host pathogen interaction: pathogen must: survive in inhospitable human body(ph, temp etc); avoid/mod immune response to allow own survival :. Avoid innate: 1) prevent opson 2) shut down tlrs 3) prevent gpcr 4) disrupt phagocyt 5) killing immune cells: avoid opsonization avoid c", ab binding:. Phagocytosis good survival mech for ec pathogens. Ex: lyme disease(borellia): coat surface w/ factor h=inhibit c" deposits by exotoxin(cspa) binding fach. Ex: syphilis(treponema): coat surface w/ host proteins to hide ag/cell surface from ab+c": syphilia sticky :. non-specific binding to charged lipids in bac mem, hides own ag.
