BIOL 102 Chapter Notes - Chapter 18: Histidine, Gene Expression, Microrna
25 Aug 2016
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Identify the different levels of gene regulation in eukaryotes. Describe chromatin structure and how it differs in active versus inactive genes. Compare and contrast how the transcription of multiple genes, involved in the same cellular response, is coordinated in bacteria and eukaryotes. Describe alternative splicing and how it is regulated. Describe the different mechanisms for controlling mrna stability. Describe translational and post-translational control in eukaryotes. Describe how defects in gene regulation can lead to cancer. Differential gene expression: responsible for creating different cell types, arranging them into tissues and coordinating their activity to form multicellular society we call an individual. 6 levels of control: chromatin remodelling, transcription, rna processing, mrna stability, translation, posttranslational modification (folding, glycosylation, transport, activation and degradation of protein) For the arrival of a signalling molecules from outside the cell to result in transcription of a particular gene the chromatin around the target gene needs to be remodelled. Most abundant dna-associated proteins are called histones.
