PHAR 100 Chapter Notes - Chapter 25: Aspergillus Flavus, Polychlorinated Biphenyl, Aniline
11 Nov 2016
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Lesson f1 drugs, chemicals and cancer; drugs used for the treatment of cancer. Outline the historical development of knowledge of the relationship between selected chemicals and cancer. Describe the major types of cancer responsible for death in men and women. List the major causes of cancer in humans. List chemicals which are carcinogenic in people. Describe current ideas of the mechanism by which chemicals cause cancer. Describe methods which are used for testing chemicals for carcinogenicity. Describe the possible aims of cancer chemotherapy. Describe the principles of cancer chemotherapy, benefit versus risk, mechanisms, adverse effects, combination therapy. Classify agents used for cancer chemotherapy into 6 groups. 1775 percival pott, london, england surgeon described cancer of the scrotum; related it to chronic exposure to soot. 1895 bladder cancer was described by rehm in aniline dye workers (use of 2- 1910 clunet in france demonstrated that exposure of rats to x-rays caused cancer.
