PHAR 100 Chapter Notes - Chapter 4: Mifepristone, Cell Membrane, Seminiferous Tubule

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Jeanne Mulder William Racz

Document Summary

It causes various adverse effects such as kidney toxicity. Imidazoles (or azoles): the imidazoles (e. g. ketoconazole, fluconazole) are effective when taken orally for systemic fungal infections. It inhibits a fungal cytochrome p450, thereby inhibiting ergosterol synthesis: the selective toxicity of the azoles lies in their higher affinity for the fungal p450 than the human p450s that are involved in drug metabolism. Answer: the p450 family of enzymes are responsible for the metabolism of the vast majority of clinically used drugs (module 1). Virus: small, infectious agent only able to multiply within the living cells or other organisms, including animals, plants, and bacteria. It can be deadly, and there is a great need for additional and more effective antiviral drugs. It is selective for cells that are infected with the virus herpes: useful in combatting infection due to varicella zoster virus (vzv) (virus that causes chicken box and shingles).