PATH 3610 Chapter Notes - Chapter 12: Leptospirosis, Polydipsia, Vomiting
27 Mar 2018
School
Department
Course
Professor
Document Summary
Production of ultrafiltrate is done by regulating intraglomerular blood pressure. Renin converts angiotensinogen to angio 1, angiotensin converting enzyme (ace) convert angio 1 to angio 2. Efferent arteriole contract and increase pressure across glomerular capillary. Renal tubular epithelial cells are stable and can heal by regeneration (if framework intact) Glomeruli and interstitial cells have limited ability to regenerate and lead to fibrosis renal injury. Kidneys unable to maintain function above a minimal level (able to detect changes) Can be identified when 70% of nephron is lost. Renal diseases occurs before renal function changes. Can occur with normal kidneys or chronic renal failure. Anuria / oliguria : deficient urine production. Azotemia and uremia: either increased n waste products in blood (azotemia) or azotemia and illness with systemic signs (uremia) Dehydration, shock, heart failure are common reasons. Usually target one part of the nephron and affects the whole nephron. Obstruction of ureters or urethra (including prostatic disease)
