ANTC67H3 Chapter Notes - Chapter 8 (sections 8.1-8.3, 8.5 & 8.6): Cohort Study, Population Study, Multiple Comparisons Problem
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Clear hypothesis should include: clear definition of the exposures and outcomes of interest. Usually used after hypothesis has been explored in other cheaper types of studies. Study population depends on the hypothesis under investigation. Chosen cohort may be general population or narrowly defined populations. Cohort may be chosen because of high exposure to suspected etiological factor, particular type of treatment, or occupation hazard. General population can be drawn from geographically defined area; survey to establish baseline exposure status. Advantage: allows large number of common exposures to be considered in relation to a large number of outcomes. Can draw population cohort from well defined socio-professional group of individuals. Select an appropriate comparison group of unexposed individuals. Unexposed group should be as similar as possible to the exposed. Types of comparisons groups: internal and external. Internal comparison group - general population cohorts tend to be heterogenous with respect to many exposures so their members can be classified into different exposure categories.
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